Posted by Frank Griffo, L.Ac. | Griffo Botanicals on Mar 30th 2026
MenoCare: The Clinical Evolution of Er Xian Tang and Er Zhi Wan
MenoCare: The Evolution of Classical Wisdom for the Modern Transition
When I first began my journey into manufacturing, I spent a lot of time reflecting on the names we give our formulas. In Chinese Medicine, names are rarely arbitrary; they are poetic maps of clinical function. One of the most intriguing names in our Materia Medica is Er Xian Tang, or the Two Immortals Decoction. The name refers to its two primary ingredients, Xian Mao and Xian Ling Pi, both of which contain the character for immortal. But it also hints at the goal of the formula: to restore a sense of vitality and longevity during one of the most volatile transitions in a woman’s life.
As I saw more patients in my own clinic struggling with menopause, I realized that while Er Xian Tang was a brilliant invention, it often needed more support to handle the complexities of the modern patient. This is why we created MenoCare. It is not just a copy of a classic; it is a clinical evolution that bridges the gap between the 1950s Shanghai hospitals where Er Xian Tang was born and the high-stress, depletion-heavy environment of today. By combining the foundations of Er Xian Tang and Er Zhi Wan, we have created a formula that addresses both the fire and the foundation.
Find MenoCare: The Evolution of Er Xian Tang
The Foundation: The Two Immortals and the Two Solstices
To understand MenoCare, we have to look back at its roots. Er Xian Tang was developed in the late 1950s by Professor Zhang Bo-na at the Shanghai University of Traditional Chinese Medicine. It was designed specifically for menopausal syndrome characterized by Kidney Yin and Yang deficiency with floating Fire. This was a radical idea at the time because it used warming Yang tonics like Xian Mao and Yin Yang Huo (Xian Ling Pi) alongside cooling herbs like Zhi Mu and Huang Bo. The brilliance of this formula lies in its ability to warm the Kidney Yang to address fatigue and coldness, while simultaneously clearing the empty heat that causes hot flashes.
However, in my clinical experience, many women in the menopausal transition suffer from a deeper level of Essence depletion that requires a more substantial Yin anchor. This is where Er Zhi Wan, or the Two Ultimate Pill (sometimes called the Two Solstice Pill), comes in. Traditionally composed of Nu Zhen Zi and Mo Han Lian, Er Zhi Wan gets its name from the times of year its herbs are harvested: the winter and summer solstices. These herbs represent the ultimate points of Yin and Yang in the natural cycle. Together, they nourish the Liver and Kidney Yin without being cloying or heavy, providing a cooling, grounding influence that complements the active, warming nature of the Two Immortals.
Our Modifications: Addressing the Modern Clinical Presentation
While the combination of Er Xian Tang and Er Zhi Wan is powerful, I found that modern patients often present with a specific type of heat that is more stubborn and restless than what the classics describe. We live in a world of constant stimulation, which often leads to what Bensky and other scholars refer to as steaming bone disorder or deep-seated deficiency heat. To address this, we made several key modifications to the base formula.
We integrated Di Gu Pi (Lycium Root Bark) and Yin Chai Hu (Stellaria Root) into MenoCare. These herbs are specialists at clearing heat from the Blood and the marrow without damaging the Yin. As noted in the literature from the perspective of Walk Along the River, these herbs are essential when the heat is not just on the surface but feels like it is coming from the bones themselves. We also included Mu Dan Pi (Tree Peony Root Bark) and Sheng Di Huang (Raw Rehmannia) to further cool the Blood and nourish the fluids. This turns the formula from a simple Yin-Yang balancer into a sophisticated temperature regulator for the entire system.
Modern Research and Clinical Application
Modern pharmacology has shed light on why this combination is so effective. Studies on Er Xian Tang have shown that it can modulate the hypothalamus-pituitary-ovarian axis, helping to stabilize hormone levels naturally. Research highlighted by Chen and Maclean points out that the ingredients in these formulas have estrogen-like effects on bone density and cardiovascular health, without the risks associated with synthetic hormone replacement therapy.
In your clinic, I recommend MenoCare for the patient who feels both depleted and overheated. They may have cold feet but intense night sweats, or feel exhausted during the day but restless and anxious at night. As Jiao Shu-de suggests in his lectures, the key to treating these complex patterns is to use medicinals that can enter multiple channels and address multiple layers of the body simultaneously. MenoCare does exactly this, providing a comprehensive solution for the Spleen, Lung, and Kidney channels.
The Griffo Method: The Science of Superior Extraction
One of the most important things I want my professional customers to understand is that the efficacy of a formula like MenoCare depends entirely on how it is made. In our lab, we use what we call the Griffo Method. Many of the herbs in MenoCare, such as Xian Mao and Yin Yang Huo, contain complex flavonoids and alkaloids that are best captured in an alcohol medium. However, the cooling, nourishing herbs like Sheng Di Huang and the polysaccharides found in the roots are best extracted in water.
If you use a simple cold-maceration tincture, you miss the heavy, mineral-rich decoction that makes TCM so effective. If you use a simple powdered extract, you may lose the volatile components. Our dual-extraction process involves a long, temperature-controlled water decoction followed by a high-grade alcohol extraction. We then combine these two phases to ensure that every bottle of MenoCare contains the full spectrum of the plant's medicine. This results in a tincture that is dense, aromatic, and highly bioavailable. When you taste it, you can feel the weight of the minerals and the vibrancy of the active compounds.
Explore our MenoCare Dual-Extraction Tincture
Summary: A Balanced Path Through the Change
Menopause does not have to be a time of suffering. It is a natural transition, a change of seasons that requires a shift in how we nourish the body. By honoring the classical foundations of the Two Immortals and the Two Solstices, and refining them with modern clinical modifications and superior extraction techniques, we provide a tool that helps women move through this phase with grace and vitality. MenoCare is more than just a menopause formula; it is a commitment to the long-term health and resilience of our patients.
References & Further Reading:
Bensky, D., Clavey, S., & Stöger, E. (2004). Chinese Herbal Medicine: Materia Medica.
Chen, J. K., & Chen, T. T. (2004). Chinese Medical Herbology and Pharmacology.
Jiao, S. (2003). Ten Lectures on the Use of Medicinals.
Maclean, W., & Lyttleton, J. (2010). Clinical Handbook of Chinese Herbs: Desk Reference.
Zhang, B. (1958). Original studies on Er Xian Tang. Shanghai University of Traditional Chinese Medicine.